PUP Sta. Mesa, Manila, with 10.71 hectares, hosts the core cluster of academic buildings and services. Entering the campus is greeted by the PUP Pylon and Mural, which serve as icons of the university.
The first building built on the site is the Main Academic Building, which was originally intended to be a housing tenement. The Main Library, known as Ninoy Aquino Library and Learning Resources Center.